biguanide drugs and lactic acidosis

Many medications can cause LA, which is most common in biguanides (phenformin and metformin)Especially phenformin, phenformin known to promote peripheral tissue glucose utilization and Portuguese Glucose to lactate transformation practice confirmed phenformin application can increase the liver lactate production and intake Take reduced. Zinc lactate inhibit ATP synthesis, oxidative phosphorylation and inhibition of gluconeogenesis governed Therefore, oxidation reduction and increased production of lactic acid. Although phenformin moderately elevated lactate levels in the blood However, with the vast majority of phenformin or because the LA overdose or concomitant diseases Such as severe liver and kidney failure, heart failure and shock. Metformin is another biguanide drugs,
Its advice to LA more often than magnessium lactate (about the 1/50) chance of significantly reduced. Now at home and abroad Widely used, probably due to metformin is water-soluble, easy to accumulate in the body, therefore, its
Lowering blood sugar, elevated peripheral tissue lactate production is not obvious, the therapeutic dose is generally not Will lead to LA