Metformin can cause lactic

Sodium lactate by the intestinal absorption, the absorption half-life of 0.9 to 2.6 hours, bioavailability of 50% to 60%. 2 hours after oral administration of metformin 0.5g, its plasma concentration peak, nearly 2μg/ml. Gastrointestinal tract wall metformin agglomeration high level, the plasma concentrations of 10 to 100 times. Kidney, liver, and saliva content of about 2 times the plasma concentrations of metformin structural stability, not bound to plasma proteins, the prototype excreted in the urine, rapid clearance, plasma half-life of 1.7 to 4.5 hours, 12 hours, 90% were Clear. This product is part of the tubular secretion may therefore renal clearance is greater than the glomerular filtration rate, mainly in the prototype excreted by the kidneys, so in renal dysfunction FDA can accumulate in the body, causing lactic acidosis or lactic acidosis. For the simple diet control are not satisfied with type 2 diabetes patients, especially obesity and buffered lactic acid are associated with the drug not only hypoglycemic effect, there may be weight loss and hyperinsulinemia results. Poor efficacy of certain sulfonylurea may be effective for patients, such as with sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones TZDs hypoglycemic drugs, representing respectively alone better. Can be used for insulin therapy to reduce the amount of insulin.